Sulfamethoxazole and trimethoprim Uses, Side Effects & Warnings

Avoid coadministration of BACTRIM with drugs that are substrates of CYP2C8 and 2C9 or OCT2. For the treatment of traveler’s diarrhea due to susceptible strains of enterotoxigenic E. Bactrim may interact with many drugs; the patient and prescribing doctor should be aware of any potential interactions. Your dosage will depend on your age, your medical condition, the formulation you use, and other factors.

  1. This medicine will not work for colds, flu, or other virus infections.
  2. Your doctor will determine the best dosage to fit your childs needs.
  3. Bactrim and Bactrim DS are FDA-approved to treat acute (sudden or short-term) worsening of chronic bronchitis in adults.
  4. Many people using this medication do not have serious side effects.

Although not all of these side effects may occur, if they do occur they may need medical attention. If you cannot avoid being in the sun, wear protective clothing and sunscreen. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. For patients taking the oral liquid, use a specially marked measuring spoon or other device to measure each dose accurately.

What are the side effects of Bactrim (Sulfamethoxazole and Trimethoprim Oral/Injection)?

Its half-life is 6 to 12 hours, increasing to between 20 and 50 hours in renal failure. Trimethoprim has a half-life of 8 to 10 hours, is minimally metabolized in the liver, and is primarily excreted in the urine, essentially unchanged. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Approximately 70% of sulfamethoxazole and 44% of trimethoprim cbd addiction are bound to plasma proteins. The presence of 10 mg percent sulfamethoxazole in plasma decreases the protein binding of trimethoprim by an insignificant degree; trimethoprim does not influence the protein binding of sulfamethoxazole. In vitro studies suggest that trimethoprim is a substrate of P-glycoprotein, OCT1 and OCT2, and that sulfamethoxazole is not a substrate of P-glycoprotein.

BACTRIM is contraindicated for infants younger than 2 months of age (see INDICATIONS and CONTRAINDICATIONS sections). Like other drugs containing sulfonamides, BACTRIM can precipitate porphyria crisis and hypothyroidism. Avoid use of BACTRIM in patients with porphyria or thyroid dysfunction. In glucose-6-phosphate dehydrogenase deficient individuals, hemolysis may occur. Trimethoprim is an inhibitor of CYP2C8 as well as OCT2 transporter.

The two active ingredients work together to prevent a chemical many bacteria need to grow. Talk to your care team about the use of this medication in children. While this medication may be prescribed for children as young as 2 months for selected conditions, precautions do apply.

During administration of 800 mg sulfamethoxazole and 160 mg trimethoprim b.i.d., the mean steady-state plasma concentration of trimethoprim was 1.72 μg/mL. The steady-state mean plasma levels of free and total sulfamethoxazole were 57.4 μg/mL and 68.0 μg/mL, respectively. These steady-state levels were achieved after three days of drug administration.1 Excretion of sulfamethoxazole and trimethoprim is primarily by the kidneys through both glomerular filtration and tubular secretion.

Dosage for urinary tract infections (UTI)

Sulfamethoxazole alone was positive in an in vitro reverse mutation bacterial assay and in in vitro micronucleus assays using cultured human lymphocytes. The trimethoprim component of BACTRIM has been noted to impair phenylalanine metabolism, but this is of no significance in phenylketonuric patients on appropriate dietary restriction. Our Bactrim DS Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.


Bactrim may also be used off-label for other conditions. Off-label drug use is when an FDA-approved drug is prescribed for a purpose other than what it’s approved for. Call your doctor right away if you have an allergic reaction to Bactrim, as the reaction could become severe.

How to use Sulfamethoxazole-TMP DS Tablet

In a separate survey, Brumfitt and Pursell also found no congenital abnormalities in 35 children whose mothers had received oral sulfamethoxazole and trimethoprim at the time of conception or shortly thereafter. Cases of hypoglycemia in non-diabetic patients treated with BACTRIM are seen rarely, usually occurring after a few days of therapy. Patients with renal dysfunction, liver disease, malnutrition or those receiving high doses of BACTRIM are particularly at risk. Cough, shortness of breath and pulmonary infiltrates potentially representing hypersensitivity reactions of the respiratory tract have been reported in association with sulfamethoxazole and trimethoprim treatment. The usual adult dosage in the treatment of acute exacerbations of chronic bronchitis is 1 BACTRIM DS (double strength) tablet or 2 BACTRIM tablets every 12 hours for 14 days.

Patients allergic to sulfa compounds should not take Bactrim. Sulfamethoxazole and trimethoprim combination is an antibiotic. It works by eliminating the bacteria that cause many kinds of infections.

Or it may be caused by consuming water that contains different bacteria than what your body is used to at home. Symptoms commonly include trouble breathing, chest pain, and fever. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.

Sign up for free and stay up to date on research advancements, health tips, current health topics, and expertise on managing health. This medicine is available only with your doctor’s prescription. Follow your doctor’s instructions carefully when using this medicine. Stopping Bactrim too soon can cause your infection to come back. You should feel better within a few days of starting on Bactrim.

Contact your care team right away if you notice fevers or flu-like symptoms with a rash. The rash may be red or purple and then turn into blisters or peeling of the skin. Or, you might notice a red rash with swelling of the face, lips or lymph nodes in your neck or under your arms. This list is not complete and many other drugs may affect Bactrim DS. Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication.

Severe and symptomatic hyponatremia can occur in patients receiving BACTRIM, particularly for the treatment of P. jirovecii pneumonia. Evaluation for hyponatremia and appropriate correction is necessary in symptomatic patients to prevent life-threatening complications. Bactrim drug overdose: definition risks signs and more is available in tablets in two strengths; 400 mg sulfamethoxazole and 80 mg trimethoprim and the “DS” form which means double strength, 800 mg sulfamethoxazole and 160 mg trimethoprim. Patients should follow their doctor’s instructions and take all of the Bactrim prescribed.

Sulfamethoxazole and trimethoprim are a medication that comes in tablet form to treat bacterial infections. You can take this medication by mouth with a glass of water as directed. Prescribing clinicians, including nurse practitioners, primary care providers, physician assistants, and internists who prescribe trimethoprim/sulfamethoxazole (TMP-SMX), should be familiar with ints indications and adverse effects.

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